Pol E: A Key Enzyme in DNA Replication and Cancer (P28455)

Target Name: DNA Polymerase epsilon

NCBI ID: P28455

DNA Polymerase epsilon

Other Name(s): Pol e

Pol E: A Key Enzyme in DNA Replication and Cancer

DNA polymerase epsilon (Pol e) is an enzyme that plays a critical role in the replication of DNA in eukaryotic cells. It is a member of the DNA polymerase family 1 and is responsible for the synthesis of the working copy of the double helix in the presence of DNA templates, primers, and the four free nucleotides. Pol e is a protein that contains 264 amino acids and has a calculated molecular weight of 31 kDa.

Pol e is a key enzyme in the DNA replication process, as it ensures that the new double helix is 鈥嬧?媠ynthesized correctly and in the correct order. It is also involved in the repair of DNA damage and has been shown to play a role in the regulation of gene expression.

One of the unique features of Pol e is its ability to recognize specific sequences in DNA. This is accomplished through the use of a special domain called the \"T-loop,\" which is a short loop of amino acids that is located at the base of the third helix. The T-loop is able to bind to specific DNA sequences and facilitate the initiation of the DNA replication process.

In addition to its role in DNA replication, Pol e is also involved in the regulation of gene expression. This is accomplished through the use of a process called \"DNA-protein interaction,\" which allows the enzyme to bind to specific DNA sequences and regulate the activity of the cell's transcription factors. This has been shown to play a role in the regulation of cell growth, differentiation, and the development of cancer.

Another unique feature of Pol e is its ability to recognize and repair DNA damage. This is accomplished through the use of a process called \"base repair,\" which allows the enzyme to recognize and repair incorrectly base pairs in the DNA. This has has been shown to play a role in the regulation of gene expression and the development of cancer.

Due to its involvement in the regulation of DNA replication, Pol e is a potential drug target for a variety of diseases. For example, Pol e has been shown to be involved in the development of cancer, and inhibitors of Pol e have been shown to be effective in treating certain types of cancer. Additionally, the regulation of Pol e activity has been implicated in a variety of diseases, including neurodegenerative diseases, autoimmune diseases, and TABLET-related diseases.

In conclusion, DNA polymerase epsilon (Pol e) is a critical enzyme in the replication of DNA in eukaryotic cells. It is a protein that plays a vital role in the regulation of gene expression and the development of cancer. As a result, it is a potential drug target for a variety of diseases. Further research is needed to fully understand the role of Pol e in disease and to develop effective treatments.

Protein Name: DNA Polymerase Epsilon

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